Amiodarone increases plasma digoxin concentrations.

Amiodarone with digoxin

Nov 6, 2016. The amiodarone digoxin interaction is one that every pharmacist should know. Here's what to expect along with a few other clinical pearls. Amiodarone-digoxin interaction: clinical significance, time course of development , potential pharmacokinetic mechanisms and therapeutic implications. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pha...

Falsely raised plasma digoxin concentrations in liver disease.

Plasma and tissue digoxin concentrations in patients undergoing cardiopulmonary bypass.

Plasma myocardial, and skeletal muscle digoxin concentrations were measured in 32 patients undergoing cardiopulmonary bypass who were on long-term treatment with digoxin. The patients were divided into 4 groups according to the daily digoxin dose and the interval between discontinuation of the drug and operation. Before bypass, the mean digoxin concentrations were 1.58 nmol/l (1.24 ng/ml) in pl...

Plasma and myocardial digoxin concentrations in patients on oral therapy.

Methods are now available which are sensitive enough to detect digoxin concentration to levels of 5 mug./ml. Hitherto the degree of sensitivity of specific chemical methods was not acceptable for clinical application. Digoxin-specific antibodies have recently been prepared (Butler and Chen, 1967), and a test based on the radioimmunoassay principle has now been used to measure plasma digoxin lev...

Plasma digoxin concentrations in patients on admission to hospital.

Plasma digoxin concentrations on emergency admission to hospital were measured by radioimmunoassay in 10I patients who had been taking chronic maintenance digoxin therapy. The mean concentration was I4I nglml. Fifty-eight patients had plasma levels outside the range o-8 to 2-0 nglml: of these, 33 patients had levels below o-8 ng/ml and may not have been given sufficient digoxin, while 25 patien...